Category Archives: Bacteria

Birthdays, TB and Thank yous! JIDC News — January 2012

As you read last week, I am looking forward to New Science Year 2012.

One reason for my excitement is the January 2012 edition of JIDC, which is a special issue on TB. I will be featuring posts this month and in February on TB to coincide with the TB JIDC issue, including a TB post from Amber, our Editor’s Picks contributor.

This year also marks JIDC’s fifth birthday! Happy Birthday, JIDC! August 2012 will be the official anniversary of our first issue, which was published in August of 2007.

Editor-in-Chief Salvatore Rubino has written an excellent editorial on the five years of JIDC in the current January issue, which you can read here. In summary, Prof. Rubino describes the tremendous growth of JIDC as the journal moved from a bimonthly format to monthly format and notes our acceptance into PubMed in 2009 –  a major accomplishment that allows the articles by our authors to reach a wide professional audience.

Importantly JIDC could not function without the extraordinary contributions from scientists, writers, educators, health officials and students worldwide. There is no doubt that JIDC would not be as successful without these people.

Manuscript reviews are a critical component of a functioning scientific community. A reviewed and accepted manuscript signifies scientific studies and findings that have been acknowledged by experts in the field. As a scientist, having your work reviewed allows the perspectives of others to inform your work and identify possible flaws in the methods, results and/or interpretations. Reviewers’ suggestions and manuscript discussion can often lead to improved research since it is not always possible to have an unbiased view of your own work from the inside and out. We would like to thank everyone who contributed to the global scientific community by reviewing JIDC manuscripts in 2011. Below you can see that JIDC reviewers are international experts representing 65 countries acround the globe. I find this truly amazing.

Lorena Abadia-Patino (Venezuela) , Ibrahim Abdel-Messih (Italy), Yusuf Abdu Misau (Nigeria), Hikmate Abriouel (Spain), Ishag Adam (Sudan), Mohammad Aghasadeghi (Iran), Kabiru Akinyemi (Nigeria), Onoja Akpa (Nigeria), Bolajoko Aina (Nigeria), Raquel Almansa (Spain), Sitara Ajjampur (India), Carlos Alencar (Brazil), Abdulghani Alsamarai (Iraq), Patricia Agaba (Nigeria), Saurabh Agarwal (India), Deepak Aggarwal (United States), Jaffar Al-Tawfiq (Saudi Arabia), Carlos Amabile-Cuevas (Mexico), Malaka Amer (Saudi Arabia), Ben Amos (Tanzania), Vicente Antonello (Brazil), Maria Appleman (United States), Liana Ariza (Brazil), George Araj (Lebanon), Antonio Arbo (Paraguay), Carmen Ardanuy (Spain), Elisabete Arrese (Spain), Ifedayo Adetifa (Gambia), Samar Al-Nahhas (Syria), Ibrahim Al-Traif (Saudi Arabia), Jazzmin Arrivillaga (Venezuela), Myo Aung (Thailand), Reham A. Aziz (Egypt), Sina Aziz (Pakistan) Ahmed Al-Naaimi (Iran), Clement Azodo (Nigeria), Parisa Badiee (Iran), Ahmet Balik (Turkey), Frederick Baliraine (United States) , Kristin Banek (Uganda), Bita Bakhshi (Iran), Stephen Baker (Vietnam), Mustafa Bakir (Turkey), Fukai Bao (China), Oussama Baraket (Tunisia), Ladaporn Bodhidatta (Thailand), Andreas Baumler (United States), Wafaa Bakr (Egypt), Matteo Biasotto (Italy), Norma Binsztein (Argentina), Joseph Bliss (United States), Eve Boakes (United Kingdom), Steven Bosinger (United States), Giuseppe Botta (Italy), Zulkif Bozgeyik (Turkey), Maria Braoudaki (Greece), John Bremner (Australia), Rama Bhunia (India), Mathilde Boon (Netherlands), Franco Buonaguro (Italy), Cyrille Bisseye (Burkina Faso), Jorge Cabral (Portugal), Adrian Canizalez-Roman (Mexico), Jean-Philippe Chippaux (France), Andrea Carai (Italy), Nishat Chowdhury (Bangladesh), Lance Christiansen (United States), Phillip Collier (United Kingdom), Mauro Colombo (Italy), Daniela Ceccarelli (Italy), Solmaz Celebi (Turkey), Changfa (Clark) Cui (United States), Marie Chattaway (United Kingdom), Giancarlo Ceccarelli (Italy), Ricardo Correa (Panama), Carlos Canelo-Aybar (Peru), Nikoloz Chkhartishvili (Georgia), Rajesh Chudasama (India), Celso Cunha (Portugal), Nihar Dash (United Arab Emirates), Terezinha da Silva Leitao (Brazil), Monica da Silva-Nunes (Brazil), Barun Kumar De (United States), Monorama Deb (India), Debmita Debdas (India), Bouke De Jong (Belgium), Mireya de la Garza (Mexico), Giovanni Delogu (Italy), Jacobus de Waard (Venezuela), Elisa Deriu (United States), İlker Devrim (Turkey), Antonina Dolei (Italy), Gerusa Dreyer (Brasil), Maria Drogari-Apiranthitou (Greece), Milena Dropa (Brazil), Renu Dutta (India), Shanta Dutta (India), Mohamad Elsweify (Saudi Arabia), Atef El-Gendy (Egypt), Sabry El-Naggar (Egypt), Şevval Eren (Turkey), Abdul-Naser Elzouki (Libya), Teresa Estrada-Garcia (Mexico), Mônica Facanha (Brazil), Heriberto Fernandez (Chile), Joseli Ferreira (Brazil), Parissa Farnia (Iran), Mel Figtree (Australia), Joseph Forbi (Nigeria), Lucia Galli (Italy), R. Glenn Gaston (United States), Gerardo González-Rocha (Chile), P. Grabarczyk (Poland), Javier Garaizar (Spain), Marina Giuliano (Italy), Deniz Gur Akman (Turkey), Tayyaba Ijaz (Pakistan), Noyal Joseph (India), Yadav Prasad Joshi (Nepal), Wafa Habbal (Sirya), Xiang Han (United Stetes), Azian Harun (Malaysia) , Abdul Haque (Pakistan), Zahra Hasan (Pakistan), Mary Hoelscher (United States), Richard C. Huard (United States), Entesar Husain (Kuwait), Murat Kapan (Turkey), Ismail Kapicioglu (Turkey), Oguz Karabay (Turkey), Salim Abdool Karim (South Africa), Supaletchimi Katherason (Malaysia), Rumeyza Kazancıoğlun (Turkey), Adnan Khan (Pakistan), Karen Keddy (South Africa), Abdullah Kilic (Turkey), Paul Klatser (Netherlands), Diamantis Kofteridis (Greece), Michael Koster (United States), Anil Kumar (India), J. Labbe (New Caledonia), Lincoln Lau (Hong Kong), Sisinnio Leori (Italy), Benedikt Ley (Austria), Ming-Li Liou (Taiwan), Jean Limongi (Brazil), Amanda Loftis (Saint Kitts and Nevis), Zhigang Liu (United States), Chun-Yi Lu (Taiwain), Eric Macy (United States), Emin Maden (Turkey), Evelyn Madoroba (South Africa), Stanley Maloy (United States), Daniel Marcano (Venezuela), Margarita Martinez-Medina (Spain), Humphrey Mazigo (Tanzania), Jacobe Mathew (India), Mark Melzer (United Kingdom), Juliane Meng-Hentschel (Germany), Vitaliano Muzii (Italy), Lucky Moehario (Indonesia), Denise Patricia Mawili-Mboumba (Gabon), Leigh Miller (Thailand), Santosh Mondal (India), David Murdoch (New Zealand), Reggie Mutetwa (Zimbabwe), Nutan Mytle (USA), Joseph Mwanzia Nguta (Kenya), Gholamreza Nikbakht Brujeni (Iran), Vishal Nigam (India), Carla Novais (Portugal), Samuel Ola (Nigeria), Obeid Obeid (Saudi Arabia), A. B. Olokoba (Nigeria), Bianca Paglietti (Italy), Tibor Pal (United Arab Emirates), Dimple Panwar (India), Georgios Pappas (Greece), Violeta Pardío (Mexico), Luis Pianciola (Argentina), Ariel Pereda (Argentina), Alicia Perez (France), Celeste Pérez (Argentina), Cristian Perez (Costa Rica), Mrudula Phadke (India), Guillermo Pimentel (United States), Aggeliki Poulou (Greece), Farhad Pourfarzi (Iran), Audino Podda (Italy), Mayoor Prabhu (India), Pradyot Prakash (India), Zhikang Qian (United States), Manuela Raffatellu (United States), Md Siddiqur Rahman (Bangladesh), Paola Rappelli (Italy), Ayalu Reda (Ethiopia), Ana Carolina Ritter (Brazil), Octavio Rivero (Spain), Alesia Romanovkaya (Russia),Jane Rose (Saint Kitts and Nevis), Joaquim Ruiz (Spain), Suleiman Saidi (Kenya), Eisa Salehi (Iran), Sandeep Saluja (India), Vittorio Sambri (Italy), Amy Sapkota (United States), Sanda Sardelic (Croatia), Shiv Sarin (India), Murat Sayan (Turkey), Dianella Savoia (Italy), Karin Schwaiger (Germany), M Elena Seoane (Spain), Burcin Sener (Turkey), Asa Sjoling (Sweden), Abubaker Sidahmed (Canada), Nidhi Singla (India), Herman Sprenger (Netherlands), Ajanta Sharma (India), Seyed Davar Siadat (Iran), Addmore Shonhai (South Africa), Kirill Sharshov (Russia), VN Sehgal (India), Michael Seckeler (United States), Pierre Smeesters (Belgium), Malini Shariff (India), Wei Sun (United States), Olusegun Soge (United States), Bahman Tabaraie (Iran), Irene Tami (United States), Reda Tagajdid (Morocco), Narhari Timilshina (Canada), Mohammed Timinouni (Morocco), Eduardo Tondo (Brazil), Hasan Ucmak (Turkey), Uade Ugbomoiko (Nigeria), Kingsley Ukwaja (Nigeria), Maria Leide Wand-del-Rey Oliveira (Brazil ), Tjip van der Werf (Netherlands), A Veloo (Netherlands), Tommie Victor (South Africa), Roberto Vidal (Chile), Ha Vinh (Vietnam), Jugsharan Virdi (India), Simonetta Viviani (France), Georgia Vrioni (Greece), Richard Vincent (Madagascar), Francois-Xavier Weill (France), Hannah Wexlecheck (United States), Heather Williamson (United States), Paul-Louis Woerther (France), Asnakew Yeshiwondim (United States), Raffaele Zarrilli (Italy), Dominik Zenner (United Kingdom), Roberto Zenteno (Mexico), Abdulaziz Zorgani (Libya), Pablo Zunino (Uruguay).

And thanks to Editors of JIDC and technical staff including:

 Nikki Kelvin, Marco Scano, Joey Kelvin, Jeff Coombs, Giustina Casu, Nadia Ahmod, Eve Boakes, Mark Cameron, Cheryl Cameron, Antigoni Chaidaroglou, Marie Anne Chattaway, Daniela Chessa, Amber Farooqui, Katy Harker, Jorg Heukelbach, Richard C. Huard, Adnan Khan, Patrick J. Kelly, Gemma C Langridge, Asghar Nazeer, Alicia San José, Helena Seth-Smith, Chengming Wang, Aysegul Karahasan Yagci, Dominique China, Mark David Dickson, Emily Hiltz, Lisa M. Lambert, and Eva Molak.

 Special acknowledgement to Senior Editor Aysegul Karahasan Yagci!

We also thank the financial supports of JIDC.  Without financial support, JIDC could not exist:

Alyson

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Filed under Bacteria, Countries, Editor's Pick, Infectious Disease, JIDC News, Tuberculosis

Ticks and Fleas: fortune tellers of the tropics — Amber’s Pick

Editor’s Pick by Amber for the JIDC October Issue.  Thanks Amber!

Alyson

Tick-borne diseases are a hallmark of tropical weather. One can come across pathogen laden ticks not only in the rainforest but even in kitchens, gardens, backyard compounds or on domestic animals.  These common pathogen reservoirs which can accelerate disease spread at the community level.  The end result of the spread of tick-borne diseases may be many casualties. While several tick-borne viral, protozoal and bacterial infections are known, Rickettsial diseases are thought of as the worst human rival due to its deadly outcome, which even Dr. Howard T. Riketts (the researcher credited with the discovery of Rickettsial disease) and several other investigators succumbed to in nineteenth century. Since then, the rivalry goes on…..  

Figure 1D Immunohistochemical staining of spotted fever group rickettsial antigens

 

In an article published this month in JIDC, Tribaldos et al. report the case fatalities in a family cluster of Rocky Mountain spotted fever (RMSF) in Panama. RMSF is a systemic infection caused by Rickettsia rickettsii, the Gram-negative bacterium which is transferred to humans by the bite of infected ticks that feed on domestic pets, rodents, reptiles, birds and medium or large mammals. The organism infects the endothelial lining of blood vessels resulting in vascular damage, fluid loss, and poor circulation and bleeding in vital organs, leading to death. The disease is often misdiagnosed at the initial stages due to unavailability of specialized diagnostic procedures in routine settings, especially in developing countries. This article describes the clinical presentation, the presence of the Escher lesion, and the PCR based diagnosis of Rickettsia from the autopsies of three patients who belonged to the same household. Sequence analysis and restriction fragment profiling of ompA gene and immunostaining of Rickettsial antigens further describe the disease pattern.

Figure 1c RFLP analysis of ompA

In Panama, RMSF was prevalent in the latter half of the 20th century, but very few cases with 100% mortality were observed in the last decade. Moreover, in recent years, global literature has reported an increase in RMSF cases in other Latin American countries as well as in the southeastern United States, indicating the resurgence of this disease in the neotropics.

In the current scenario, I believe that the report by Tribaldos et al. significantly contributes to a better understanding of the clinical picture of RMSF which can help save lives if a diagnosis can be made faster. 

-Amber

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Filed under Bacteria, Editor's Pick, Rickettsia rickettsii

Amber’s Pick: Light a candle

Hi everyone!  Amber has a very interesting edition of Editor’ Pick this month.  She has summarized three papers from the September issue.  This issue was dedicated to  Prof. Gianfranco Del Prete who was a prominent researcher in basic and clinical immunology with specific contributions in T cell immunology.  You can read a very special Editorial by Editor-in-Chief Salvatore Rubino dedicated to Pro. Gianfranco Del Prete in our September Issue.  Please enjoy her post!

Alyson 

Light a candle

While reading the current issue of JIDC, it was hard to select ONE paper for editor’s pick. Check out the JIDC’s September collection and you will find a feast of three excellent articles that cover many interesting aspects of plague.  The plague is a well-established biosecurity risk and one of the oldest diseases known that has claimed around 200 million human lives. According to estimates, bubonic (characterized by enlarged and tender lymph nodes), septecemic or pneumonic forms of plague cause up to 90% mortality in humans, if left untreated.

Yersinia Pestis Image from CDC Public Health Image Library

The etiologic agent of the disease, Yersinia pestis (Y. pestis) is a facultative intracellular bacterium which enters in the human body either by direct contact with infected rodents or by the bites of fleas that live on infected rodent bodies. Upon entry, the foreplay of Y. pestis through its unique signature LPS (LipoPolySaccharide (Endotoxin)) shuts down the TLR4 mediated activation of the proinflammatory host response and helps the bug to proliferate in phagocytic cells. Picture to the left from Public Health Image Library of Yersinia pestis.

In the article by Amedei et al., you will find the description of the exclusive interaction of Y. pestis with innate immune response. The authors further depict the augmented antigen presentation of the Yop proteins from Y. pestis that directly suppress T-lymphocyte activation which is pivotal to combat bacterial infections. A fine reading of T-cell mediated immunity, effector T-cell function, Th cytokine network and signaling pathways is contributed by Elios et al. The pictorial demos of the articles are just superb and help the readers to comprehend complicated stories. BTW I also love the color contrasts …

Figure 1 from D'Elios et al., JIDC 2011

Coming back to plague story, it’s very important to also be aware of disease prevention. In the third article, Sun et al. describe the issues related to the development of plague vaccines. They further discuss the pros and cons of vaccines that are presently under

Figure 1 from Sun et al., JIDC 2011

clinical trials and those that could be potential candidates in future. The authors also share their own experiences in their attempts to develop live attenuated vaccine using a genetically manipulated Y. pestis strain that does not express virulence genes in the challenging environment of host tissues.

Figure 2 from Sun et al., JIDC 2011

JIDC published these articles in memory of an eminent immunologist and a dear friend, Prof. Gianfranco Del Prete. His contributions to plague research were well received globally.

What could be better to paying tribute to a scientist than to remember him with more exciting scientific discussions! I am still thinking…..

Many people have said, “It’s better to light a candle than curse the darkness”. JIDC just did the same.

 

-Amber

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Filed under Amber, Bacteria, Editor's Pick, Infectious Disease, People, Yersinia pestis